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First patient recruited in collaborative Phase 1 study to evaluate TriMix in breast cancer patients

Brussels/Niel (Belgium), 12 February 2019 - VUB, the Vrije Universiteit Brussel, and eTheRNA immunotherapies, a clinical-stage company developing cancer immunotherapies based on its proprietary mRNA-based TriMix platform, announce the recruitment of the first patient for a collaborative TriMix-BRE study to investigate the effect of the TriMix product as neo-adjuvant treatment (treatment before planned surgery) for breast cancer patients. The study will deliver mRNA via intratumoral injection in patients with non-metastatic breast cancer before planned surgery and will recruit patients with resectable breast cancer irrespective of subtype of breast cancer.

Dr. Marian Vanhoeij, Head of the Breast Clinic of the University Hospital, UZ Brussel and principal investigator of this investigator-initiated study: “We are pleased to contribute to the further clinical development of the TriMix-platform, which has been developed at our university and is now the backbone of eTheRNA immunotherapies, a spin-off from the VUB university. While the proof of concept for the TriMix platform has been delivered in multiple studies involving melanoma patients, we are convinced of the potential for TriMix in other therapeutic areas including breast cancer. In the TriMix-BRE study, a total of 36 breast cancer patients will be enrolled at the Brussels university hospital (UZ Brussel). The TriMix product will be administered 3 times in the tumor of the patients before surgical removal or before start of neo-adjuvant chemotherapy.”