• eTheRNA
  • Join us in our mission to bring hope to patients by developing novel immunotherapies

Careers

eTheRNA has entered a new phase in its young but promising history. The company is well positioned to complete phase I and II clinical studies with its mRNA-based TriMix platform for the treatment of advanced melanoma and breast cancer. eTheRNA plays a pioneering role in the development of mRNA-therapies that deliver tumor antigens to dendritic cells.

eTheRNA groups team members who are all passionate about mRNA technology and who wish to contribute to the development of truly innovative immunotherapies that can help millions of patients by combatting their disease.

Do you share our passion and are you the best in your area? Send us your spontaneous application.

Downstream Process Scientist

General Job Description

The Downstream Process (DSP) Scientist will be responsible for development of new downstream processes for existing and new mRNA products as part of the Process Development team at the eTheRNA site in Niel. He/she works in close collaboration with the Process Development team, reports to the Senior Director Process Development, and works cross-functionally with the preclinical, production, QC team.

Responsibilities and Duties

The DSP Scientist’s duties shall include, but not be limited to:

  • Establish fast and efficient identification of downstream purification methods (filtration, column purification, diafiltration,…) which are amenable to GMP requirements
  • Establish and optimize downstream process platforms to improve product purity and reduce development/manufacturing costs
  • Deliver small scale downstream purification solutions to enable research grade mRNA manufacturing needs for preclinical studies
  • Ensure phase appropriate development and qualification of downstream processes in terms of:
    • Process definition (critical process parameters and critical quality attributes)
    • Risk assessment
    • Requirements for early stage clinical manufacturing compliant with GMP (materials, process, single use disposables, cleaning, …)
  • Ensure timely generation of development plans, protocols and reports
  • Be responsible for the timely scale up and transfer of a stable and reliable downstream process, including all necessary documentation and process description to the GMP manufacturing group
  • Support third party contract manufacturing service commissions
  • Remain conversant with relevant external technological advances
  • Participate in an expert role in PD projects

Job Requirements

  • Education:
    • Master/PhD in biotechnology/bio-engineering/life sciences

  • Experience:
    • Several years of experience in bioprocess development with an emphasis on protein purification or downstream processing. Will have hands-on experience with scale up and large-scale chromatography
    • Ability to address issues of scale-up and process optimisation (from a time and cost perspective), to create new and better ways for the organisation to be successful
    • Experience with single use disposables is an asset
    • Experience with Akta Pilot chromatography skid and Unicorn software
    • Working knowledge of safety and GMP requirements of biologics manufacturing

  • Other Qualifications, Skills and Abilities:
    • Detail-oriented and accurate in following instructions, record keeping and completion of reports
    • Able to perform experimental trouble-shooting and propose technical solutions.
    • Scientific integrity
    • Fluency in spoken and written English is a must
    • Ability to work collaboratively and communicate effectively with internal teams.
    • Well organized, well-structured, hands-on, result focused;
    • Able to work under stringent time lines
    • Enthusiastic, proactive, lead by example, flexible and able to multitask;
    • Excellent understanding of MS Office (Excel, Word, PowerPoint, Outlook).

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.

Senior Scientist mRNA Formulation

General Job Description

The Senior Scientist mRNA Formulation will join the non-clinical team focused on the design and formulation of new mRNA-based immunotherapies. He/she will report into the [Principal Scientist Non-Clinical Development].

This position is based in eTheRNA’s laboratorium in Gent – Belgium.

Responsibilities and Duties

The Senior Scientist’s duties shall include, but not be limited to:

  • Planning and supporting projects to develop RNA delivery technology;
  • Development and characterizing of novel lipid and/or polymer based mRNA formulations;
  • Theoretical and practical drafting of scientific issues and matters relating to patent law in preclinical cellular and animal-experimental systems;
  • Drive scientific and technical innovation;
  • Lead a team of scientists and technicians and have an active role in the operations of the non-clinical team;
  • Technical staff training;
  • Manage multiple projects in mRNA delivery/formulation research involving cross-functional collaboration within therapeutic areas and across departments. Provide scientific expertise, guidance and strategy to successfully bring programs to Go/No Go decisions;
  • Development of relationships with pre-clinical contract research organizations and contract manufacturers, as well as managing collaborations with other (academic and industry) research centers;
  • Participate in authorship of scientific publications and patent applications;
  • Presenting results internally and externally.

Job Requirements

  • Education:
    • PhD in a life science-oriented discipline (e.g. chemistry, pharmacy, engineering) with a sound knowledge of the specialist aspects and methods involved in biochemistry, organic chemistry or pharmaceutics, or master's degree plus several years of professional experience or comparable qualification.

  • Experience:
    • 3+ years of relevant experience in companies engaged in biotech and/or pharmaceutical development;
    • Excellent knowledge of lipid-based formulation systems;
    • Deep knowledge on the design, physicochemical characterization and evaluation of nucleic acid delivery systems
    • Demonstrated track record of independent critical thinking and scientific achievement, as demonstrated by high impact publications and patents;
    • History of leading and contributing scientifically to discovery research programs;
    • Demonstrated ability to communicate complex data sets in a clear manner to internal and external stakeholders;
    • Strong analytical, problem-solving, and decision-making skills;
    • Strong academic and industry network in nucleic acid delivery;
    • Technical skills:
      • Experience in nanoparticle formulation (microfluidics, emulsification ..) methodologies and nanoparticle characterization techniques (DLS, zeta potential, chromatography);
      • Preferably experience in polymer and lipid synthesis, purification and characterization
      • Knowledge and/or experience with mRNA and miRNAs, lncRNAs or siRNA.

  • Other Qualifications, Skills and Abilities:
    • Detail-oriented with technical skills;
    • Demonstrated strong management, leadership, organizational and interpersonal skills;
    • Ability to solve problems and execute on initiatives;
    • Ability to work collaboratively and communicate effectively with R&D teams;
    • High level of integrity and dependability with a strong sense of urgency and results orientation;
    • Well organized, well-structured, hands-on, result focused;
    • Ability to foster teamwork and a collaborative atmosphere;
    • Enthusiastic, flexible and able to multitask;
    • Ability to set priorities and take initiative and be pro-active;
    • Fluent in English;
    • Excellent understanding of MS Office (Excel, Word, PowerPoint, Outlook).

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.

Communications Associate (part-time)

General Job Description

The Communications Associate will coordinate and support the internal and external communications of the Company and will thereby ensure that its messages are consistent.

The Communications Associate will be located in Niel and will work on a part-time basis.

The Communications Associate reports into the CEO.

Responsibilities and Duties

The Communications Associate performs a wide range of duties related to the internal and external communications, including but not be limited to:

  • Manage and implement the annual communications plan;
  • Own, develop, manage and ensure compliance with corporate identity;
  • Coordinate external communication activities and content with IR and PR service providers;
  • Develop and manage internal communications programs and generate content for these programs;
  • Creative content generation for mails, newsletters and other internal communications within the Company;
  • Prepare communications collateral for external audiences;
  • Assist in media opportunities and coordinating media inquiries;
  • Manage the Company’s website and create and implement social media activities;
  • Organize presentations and presences at congresses and other national/international meetings;
  • Partner closely with (i) internal team leads and (ii) external press and public relations agencies;
  • Ensure the internal and external communications are consistent and engaging;
  • Operate within a defined budget;
  • Monitor and prepare media activity reports;
  • Be the owner of all company materials with company logo.
  • Assist in the production process of print, electronic and multimedia materials.

Job Requirements

  • Education:
    • Bachelor (preference in media, Languages or Communication) or equivalent relevant experience.

  • Experience:
    • Minimum of 2 years of relevant experience in industrial B2B communications covering both PR and IR. An understanding of the life sciences industry is a plus.

  • Other Qualifications, Skills and Abilities:
    • Fluent in written and spoken English. Knowledge of Dutch is a plus;
    • Excellent verbal and written communication skills;
    • Strong knowledge of communication practices and techniques (incl. social media and digital marketing);
    • Autonomous, eager to learn, quick learning and have eye for detail;
    • Discreet and capable of handling confidential/sensitive information;
    • Ability to solve problems and execute on initiatives;
    • High level of integrity and dependability with a strong sense of urgency and results orientation;
    • Well organized, well-structured, hands-on, result focused;
    • Ability to foster teamwork and a collaborative atmosphere;
    • Enthusiastic, flexible and able to multitask;
    • Ability to set priorities and take initiative and be pro-active;
    • Excellent understanding of MS Office (Excel, Word, PowerPoint, Outlook).

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.