• eTheRNA
  • Join us in our mission to bring hope to patients by developing novel immunotherapies

Careers

eTheRNA has entered a new phase in its young but promising history. The company is well positioned to complete phase I and II clinical studies with its mRNA-based TriMix platform for the treatment of advanced melanoma and breast cancer. eTheRNA plays a pioneering role in the development of mRNA-therapies that deliver tumor antigens to dendritic cells.

eTheRNA groups team members who are all passionate about mRNA technology and who wish to contribute to the development of truly innovative immunotherapies that can help millions of patients by combatting their disease.

Do you share our passion and are you the best in your area? Send us your spontaneous application.

QC Analytical Development Specialist

General Job Description

The QC Analytical Development Specialist is responsible for the different aspects of the method lifecycle within QC and ensures the intended use of the method throughout the product lifecycle. He/she is a hands-on person responsible for the performance of lab activities in the QC lab and assures that the commitments are delivered in due time, in line with business requirements and priorities, in compliance with the current international and Belgian laws, regulations and guidelines in general, as well as cGMP guidelines and the company’s internal standards and procedures.

Responsibilities and Duties

The QC Analytical Development Specialist’s responsibilities and duties shall include, but not be limited to:

  • Development and qualification of QC methods to support the manufacturing process and to perform, under general supervision, a variety of routine, specialized laboratory operations in the quality control of mRNA based pharmaceutical drug substances and products according to cGMP requirements and to current procedures and protocols with the aim of compliance to cGMP requirements.
  • Implementation of new or improved QC methods eg. protein impurity determination, dsRNA determination, DNase/RNase detection, … and takes ownership of the required supporting studies and procedure writing.
  • Write protocol and reports to support QC method development, qualification and investigations.
  • nteract very closely with the Process Development team in order to ensure that Process Development and QC activities are aligned.
  • Perform, report and follow up of
    • QC IPC and release testing
    • QC Stability program (long term, accelerated stability and in-use)
    • Qualifications of reagents – incoming QC
    • Environmental monitoring
  • Document and report data and results in accordance with the current procedures and GMP requirements.
  • Maintain the QC area according to the procedures and instructions.
  • Perform routinely checks of the installations, equipment and premises.
  • Perform on regular intervals routine maintenance, calibration, qualification activities
  • Warn the QC Manager in case of problems, analyze the data, help in trouble-shooting and propose technical solutions.
  • Perform failure investigations.
  • Follow training in adequacy with the function.
  • Assist in the technology transfer from product development.
  • Responsible for the logistics regarding
    • Reagents and consumable inventory management
    • QC sample inventory management & outsourced activities
    • Data Management
    • Equipment maintenance

Job Requirements

  • Education:
    • A PhD or Master degree in biotechnology, (bio)medicine or life sciences or related field or equivalent by experience.

  • Experience:
    • Minimum of 3 years of relevant experience in the field of immunology and molecular biology (can be both academic or industrial; preferably in (bio)pharmaceutical industry).
    • Good knowledge of bio-analytical quality control methods in one ore more of the following methods: qPCR, spectrophotometry, MicroBCA, ELISA, Western blot, Dot blot, Flow Cytometry, Mass Spectrometry, HPLC/UPLC, RNA/DNA capillary gel electrophoresis, sequencing, compendial methods (pH, osmolality, …) and microbiology methods (endotoxin, bioburden).
    • Good knowledge of good manufacturing practices (GMP) and/or lab quality assurance standards and practices is a plus

  • Other Qualifications, Skills and Abilities:
    • Good understanding of the method lifecycle process and its relation to the product lifecycle
    • Strong scientific knowledge in the field of immunology and molecular biology
    • Detail-oriented and accurate in following instructions, record keeping and completion of reports
    • Affinity with GMP guidelines and working in a quality-oriented environment
    • Analytical mind, risk-based thinking, result-focused;
    • Able to perform experimental trouble-shooting and propose technical solutions
    • Good organizational capacities and detailed documentation practices
    • Good knowledge of English
    • Good communication skills
    • Well organized, well-structured, hands-on, result focused
    • Able to work under stringent time lines
    • Ability to foster teamwork and a collaborative atmosphere
    • Enthusiastic, flexible and able to multitask
    • Understanding of MS Office (Excel, Word, PowerPoint, Outlook)
    • Knowledge of the following software tools are considered as a plus: Geneious Softmax Pro, 2100 Bioanalyzer Expert

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.
  • Working in a nice office with nice colleagues between Antwerpen and Mechelen

Process Development Associate

General Job Description

The Process Development Associate will be responsible for execution of hands-on process and analytical development work at the eTheRNA site in Ghent and Niel.

Responsibilities and Duties

The Process Development Associate’s duties shall include, but not be limited to performing, under general supervision, a variety of laboratory tests and experimental processes:

  • Assist in development, optimization and qualification of new techniques, processes and assays
  • Mainly focused on development of functionality/potency assays using in vitro cell culture, cell transfection, bio-assays, flow cytometry, ELISA, ELISPOT, Luminex, Western Blot, SDS-PAGE, AGE/CGE and other methods
  • Participate in lab supply ordering, (patient) sample receipt, inventory management, biobanking maintenance of equipment and lab areas
  • Data processing, data analysis and good documentation practices using electronic lab notebook, protocol- and report writing; assistance in troubleshooting experimental techniques

Job Requirements

  • Education:
    • Bachelor’s in biotechnology/laboratory science or MS in biomedical sciences or similar

  • Experience:
    • Minimum of 1-2 years of relevant experience in academic or biotech industry in a similar function.
    • Broad technical expertise and mastering of several laboratory techniques including cell culture and molecular biology
    • Working knowledge of good (clinical) laboratory practices and lab quality assurance is a plus

  • Other Qualifications, Skills and Abilities:
    • Detail-oriented and accurate in following instructions, record keeping and completion of reports
    • Able to perform experimental trouble-shooting and propose technical solutions.
    • Scientific integrity
    • Ability to work collaboratively and communicate effectively with internal teams.
    • Fluent in English;
    • Well organized, well-structured, hands-on, result focused;
    • Able to work under stringent time lines
    • Enthusiastic, proactive, flexible and able to multitask;
    • Excellent understanding of MS Office (Excel, Word, PowerPoint, Outlook)
    • Willing to work several days a week during the first months of employment from Ghent, then mainly from Niel

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.
  • Working in a nice office with nice colleagues

LNP Formulation Associate

General Job Description

The Formulation Associate will be responsible for the characterization of nanoparticles at the eTheRNA site in Ghent (and occasionally in Niel).

Responsibilities and Duties

The Formulation Associate’s duties shall include, but not be limited to performing, under general supervision, a variety of laboratory tests and experimental processes:

  • Preparation of lipid nanoparticles (LNPs) incorporating mRNA
  • Nanoparticle characterization using dynamic light scattering and zeta-potential measurements
  • Analytical techniques such as spectrophotometry, capillary gel electrophoresis, Western blot, ELISA, RiboGreen RNA quantification, extraction of mRNA from LNPs
  • In vivo immunogenicity and anti-tumor efficacy experiments in mice
  • Data processing, data analysis and good documentation practices using electronic lab notebook, protocol and report writing

Job Requirements

  • Education:
    • Bachelor’s in biotechnology/laboratory science or MS in biomedical sciences or similar + FELASA B or C certificate

  • Experience:
    • Minimum of 1-2 years of relevant experience in academia or industry
    • Broad technical expertise and mastering of several laboratory techniques
    • Working knowledge of good (clinical) laboratory practices and lab quality assurance is a plus

  • Other Qualifications, Skills and Abilities:
    • Detail-oriented and accurate in following instructions, record keeping and completion of reports
    • Able to perform experimental trouble-shooting and propose technical solutions.
    • Scientific integrity
    • Ability to work collaboratively and communicate effectively with internal teams.
    • Fluent in English;
    • Well organized, well-structured, hands-on, result focused;
    • Able to work under stringent time lines
    • Enthusiastic, proactive, flexible and able to multitask;
    • Excellent understanding of MS Office (Excel, Word, PowerPoint, Outlook)

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.
  • Working in a nice office with nice colleagues

Downstream Process Scientist

General Job Description

The Downstream Process (DSP) Scientist will be responsible for development of new downstream processes for existing and new mRNA products as part of the Process Development team at the eTheRNA site in Niel. He/she works in close collaboration with the Process Development team, reports to the Senior Director Process Development, and works cross-functionally with the preclinical, production, QC team.

Responsibilities and Duties

The DSP Scientist’s duties shall include, but not be limited to:

  • Establish fast and efficient identification of downstream purification methods (filtration, column purification, diafiltration,…) which are amenable to GMP requirements
  • Establish and optimize downstream process platforms to improve product purity and reduce development/manufacturing costs
  • Deliver small scale downstream purification solutions to enable research grade mRNA manufacturing needs for preclinical studies
  • Ensure phase appropriate development and qualification of downstream processes in terms of:
    • Process definition (critical process parameters and critical quality attributes)
    • Risk assessment
    • Requirements for early stage clinical manufacturing compliant with GMP (materials, process, single use disposables, cleaning, …)
  • Ensure timely generation of development plans, protocols and reports
  • Be responsible for the timely scale up and transfer of a stable and reliable downstream process, including all necessary documentation and process description to the GMP manufacturing group
  • Support third party contract manufacturing service commissions
  • Remain conversant with relevant external technological advances
  • Participate in an expert role in PD projects

Job Requirements

  • Education:
    • Master/PhD in biotechnology/bio-engineering/life sciences

  • Experience:
    • Several years of experience in bioprocess development with an emphasis on protein purification or downstream processing. Will have hands-on experience with scale up and large-scale chromatography
    • Ability to address issues of scale-up and process optimisation (from a time and cost perspective), to create new and better ways for the organisation to be successful
    • Experience with single use disposables is an asset
    • Experience with Akta Pilot chromatography skid and Unicorn software
    • Working knowledge of safety and GMP requirements of biologics manufacturing

  • Other Qualifications, Skills and Abilities:
    • Detail-oriented and accurate in following instructions, record keeping and completion of reports
    • Able to perform experimental trouble-shooting and propose technical solutions.
    • Scientific integrity
    • Fluency in spoken and written English is a must
    • Ability to work collaboratively and communicate effectively with internal teams.
    • Well organized, well-structured, hands-on, result focused;
    • Able to work under stringent time lines
    • Enthusiastic, proactive, lead by example, flexible and able to multitask;
    • Excellent understanding of MS Office (Excel, Word, PowerPoint, Outlook).

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.

Senior Scientist mRNA Formulation

General Job Description

The Senior Scientist mRNA Formulation will join the non-clinical team focused on the design and formulation of new mRNA-based immunotherapies. He/she will report into the [Principal Scientist Non-Clinical Development].

This position is based in eTheRNA’s laboratorium in Gent – Belgium.

Responsibilities and Duties

The Senior Scientist’s duties shall include, but not be limited to:

  • Planning and supporting projects to develop RNA delivery technology;
  • Development and characterizing of novel lipid and/or polymer based mRNA formulations;
  • Theoretical and practical drafting of scientific issues and matters relating to patent law in preclinical cellular and animal-experimental systems;
  • Drive scientific and technical innovation;
  • Lead a team of scientists and technicians and have an active role in the operations of the non-clinical team;
  • Technical staff training;
  • Manage multiple projects in mRNA delivery/formulation research involving cross-functional collaboration within therapeutic areas and across departments. Provide scientific expertise, guidance and strategy to successfully bring programs to Go/No Go decisions;
  • Development of relationships with pre-clinical contract research organizations and contract manufacturers, as well as managing collaborations with other (academic and industry) research centers;
  • Participate in authorship of scientific publications and patent applications;
  • Presenting results internally and externally.

Job Requirements

  • Education:
    • PhD in a life science-oriented discipline (e.g. chemistry, pharmacy, engineering) with a sound knowledge of the specialist aspects and methods involved in biochemistry, organic chemistry or pharmaceutics, or master's degree plus several years of professional experience or comparable qualification.

  • Experience:
    • 3+ years of relevant experience in companies engaged in biotech and/or pharmaceutical development;
    • Excellent knowledge of lipid-based formulation systems;
    • Deep knowledge on the design, physicochemical characterization and evaluation of nucleic acid delivery systems
    • Demonstrated track record of independent critical thinking and scientific achievement, as demonstrated by high impact publications and patents;
    • History of leading and contributing scientifically to discovery research programs;
    • Demonstrated ability to communicate complex data sets in a clear manner to internal and external stakeholders;
    • Strong analytical, problem-solving, and decision-making skills;
    • Strong academic and industry network in nucleic acid delivery;
    • Technical skills:
      • Experience in nanoparticle formulation (microfluidics, emulsification ..) methodologies and nanoparticle characterization techniques (DLS, zeta potential, chromatography);
      • Preferably experience in polymer and lipid synthesis, purification and characterization
      • Knowledge and/or experience with mRNA and miRNAs, lncRNAs or siRNA.

  • Other Qualifications, Skills and Abilities:
    • Detail-oriented with technical skills;
    • Demonstrated strong management, leadership, organizational and interpersonal skills;
    • Ability to solve problems and execute on initiatives;
    • Ability to work collaboratively and communicate effectively with R&D teams;
    • High level of integrity and dependability with a strong sense of urgency and results orientation;
    • Well organized, well-structured, hands-on, result focused;
    • Ability to foster teamwork and a collaborative atmosphere;
    • Enthusiastic, flexible and able to multitask;
    • Ability to set priorities and take initiative and be pro-active;
    • Fluent in English;
    • Excellent understanding of MS Office (Excel, Word, PowerPoint, Outlook).

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.