• eTheRNA
  • Join us in our mission to bring hope to patients by developing novel immunotherapies

Careers

eTheRNA has entered a new phase in its young but promising history. The company is well positioned to complete phase I and II clinical studies with its mRNA-based TriMix platform for the treatment of advanced melanoma and breast cancer. eTheRNA plays a pioneering role in the development of mRNA-therapies that deliver tumor antigens to dendritic cells.

eTheRNA groups team members who are all passionate about mRNA technology and who wish to contribute to the development of truly innovative immunotherapies that can help millions of patients by combatting their disease.

Do you share our passion and are you the best in your area? Send us your spontaneous application.

Research Associate Pre-Clinical Development

General Job Description

The Lab Technician Pre-Clinical Development is a hands-on person responsible for in vitro and in vivo tests and investigations in the field of immunotherapy. This position provides also input on the implementation, optimization and validation of new methods.

This position reports into the Principal Scientist, preclinical development.

This position will be based in Ghent.

Responsibilities and Duties

The Research Associate Pre-Clinical Development duties shall include, but not be limited to:

  • Perform, under general supervision, a variety of routine and specialized laboratory tests and animal experiments, specimen preparations and experimental procedures, assist in the use of specialized lab equipment and analysis of data generated by this equipment
  • Generation and characterization of formulations for mRNA delivery
  • Mice manipulations including injections (intravenous, intraperitoneal, subcutaneous), blood collection, induction of tumors and in vivo imaging
  • Analysis of harvested cells using techniques such as flow cytometry, ELISA, ELISPOT
  • Cell culture of human and murine cell lines and primary cells
  • Assist in the development of new assays
  • Help to troubleshoot experimental techniques, analyzing the data and reporting the experimental results
  • Maintain a detailed electronic lab book related to ongoing experiments
  • Participate in the maintenance of equipment and lab areas

Job Requirements

  • Education:
    • Professional Bachelor in Biomedical Laboratory Techniques or Master in Biomedical Sciences/Biotechnology or related field or equivalent relevant laboratory experience

  • Experience:
    • Minimum of two years of relevant laboratory experience (can be both academic or industrial)
    • Experience in cell culture and immunological assays
    • Experience in flow cytometry
    • Broad knowledge of molecular biotechnology techniques (cloning, DNA/RNA isolation, RT-QPCR, Western Blot)
    • Prior experience and interest in animal handling (FELASA B certificate mandatory)

  • Other Qualifications, Skills and Abilities:
    • Detail-oriented and accurate in following instructions, record keeping and completion of reports
    • Able to perform experimental troubleshooting and to propose technical solutions
    • Scientific integrity
    • Proficient in written and spoken English
    • Good communication skills
    • Well organized, well-structured, hands-on, result focused
    • Able to work under stringent time lines
    • Ability to foster teamwork and a collaborative atmosphere
    • Enthusiastic, flexible and able to multitask
    • Understanding of MS Office (Excel, Word, PowerPoint, Outlook)

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.

Quality Assurance Associate

General Job Description

The Quality Assurance Associate supports the continuous improvement and maintenance of the Quality Management System (QMS) within the company, under the supervision of the QA Manager, and helps to ensure that all operations comply with international cGMP regulations in general and Belgian laws and regulations in particular, as well as the company's internal standards, and assures the correct detection, reporting and closure of quality events, changes and other types of quality system related events

This position reports to the QA Manager.

Responsibilities and Duties

The Quality Assurance Associate duties shall include, but not be limited to:

  • Printing of the blanco batch records and batch related labels
  • Review of the master blanco batch records
  • Perform batch review & follow-up release of batches
  • Prepare Batch Release certificates & CoA’s
  • QA Review & Follow up of events, OOS, CAPA, change requests
  • Assess and evaluate the correctness and completeness of impact and risk assessments
  • Documentation management: keep quality records and files accordingly, revision and distribution and archiving of SOPs, reports, batch records and other documents related to the QMS
  • Establishes product quality documentation system by writing and updating quality procedures
  • QA Review of:
  •            Environmental monitoring activities
  •            Stability protocols & reports
  • Execution and participation on QA overview activities
  • Execution and participation on Internal audits
  • Keep training files up to date and inform about training status
  • Perform Line Clearances
  • Release of incoming materials
  • Release of autoclaved materials
  • Alarm handling
  • Create and update QA SOPs
  • Prepare and give QA trainings
  • Assure that good distribution practices are applied on incoming and outgoing goods
  • Record and produce meeting minutes for staff meetings and audits
  • Preparation of the annual product quality review
  • Prepare management review documentation
  • Collect internal and external data from various sources to generate reports for quality review
  • Perform supplier qualification and requalification including audits
  • Perform customer qualification and requalification
  • Assist in the planning and execution of the Validation Master plan:
  • Assist in QA and development related projects
  • Other duties as assigned

Job Requirements

  • Education:
    • Master degree, by preference in biomedicine, life sciences, pharmaceutical chemistry or equivalent relevant experience

  • Experience:
    • Minimum of 3 years of relevant professional experience with QA work
    • Working experience with a QMS, by preference in pharmaceutical environment, and GMP principles

  • Other Qualifications, Skills and Abilities:
    • Analytical mind, with focus on quality and eye for detail
    • Good data management skills: detail-oriented and accurate in following instructions, record keeping and completion of reports
    • Scientific integrity
    • Good knowledge of English and Dutch
    • Good communication skills (both oral and written)
    • Well organized, well-structured, hands-on, result focused
    • Able to prioritize work, to manage multiple tasks and to work under stringent time lines
    • Ability to foster teamwork and a collaborative atmosphere
    • Enthusiastic, flexible and able to multitask
    • Good understanding and use of MS Office (Excel, Word, PowerPoint, Outlook)

Offer

  • An exciting job in a dynamic and entrepreneurial environment with room for personal development;
  • Employment contract of unlimited duration with a competitive salary package.